Two new Spectrophotometric Approaches to the Simultaneous Determination of Ezetimibe and Atorvastatin Calcium

Abstract

Two rapid, simple and sensitive spectrophotometric methods for the quantitative analysis of ezetimibe (EZB) and atorvastatin calcium (ATVC) in bulk powder and combined tablet form have been developed and validated. The first method is bivariate calibration and the second method is ratio subtraction in conjunction with second derivative (D )spectrophotometry. These methods are tested by analyzing synthetic binary mixtures of the above drugs and they are applied to commercial pharmaceutical preparation of the subjected drugs. Standard deviation is < 2 in the assay of raw materials and tablets. Methods are validated as per ICH guidelines and statistical comparison of the suggested methods with the reported spectrophotometric one using F and t tests showed no significant difference regarding both accuracy and precision.