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Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities
(Taylor & Francis Group, 2019)Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular ... -
Therapeutic strategies for erectile dysfunction with emphasis on re cent approaches in nanomedicine
(Future University in Egypt, 2019)This review addressed erectile dysfunction, regarding pathophysiology and therapeutic strategies. The line of treatment includes phosphodiesterase type-5 inhibitors and other types of therapy like topical and stem-cell ... -
Synthesis of 5-substituted 2-ylidene-1,3-thiazolidin-4-one derivatives and evaluation of their anticancer and antioxidant activities
(Chemistry of Heterocyclic Compounds, 2019-06-26) -
Spray-Dried Silica Xerogel Nanoparticles as a Promising Gastroretentive Carrier System for the Management of Chemotherapy-Induced Nausea and Vomiting
(International Journal of Nanomedicine, 2019-12-19) -
Spectrophotometric Resolution and Quantification of Ternary Co-formulated Mixture of Thioctic acid, Benfotiamine and Cyanocobalamin
(Research J. Pharm. and Tech, 2019-04-16)Four spectrophotometric methods were developed and validated for spectral resolution and determination of thioctic acid (THC), benfotiamine (BEN) and cyanocobalamin (CNCo) in their pure form, laboratory prepared mixtures ... -
Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture
(Springer, 2019)Background: Simple, specific, accurate, and precise spectrophotometric methods are progressed and validated for concurrent analysis of pseudoephedrine sulphate (PSE) and loratadine (LOR) in their combined dosage form ... -
Smart Spectral Processing of Data for the estimation of Commonly Used Over-the-counter (OTC) Co-formulated drug; Pseudoephedrine hydrochloride and Ibuprofen
(Elsevier, 2019-07-27)Oral pharmaceutical preparation containing pseudoephedrine hydrochloride (PSE) and ibuprofen (IBU) iswidely prescribed as over- the- counter (OTC) for treatment of common cold-sinus. Development of four precise and ... -
Phytochemical profile and protective effect of Ocimum basilicum aqueous extract in doxorubicin/irradiationinduced testicular injury
(Royal Pharmaceutical Society, Journal of Pharmacy and Pharmacology, 2019-09-14)Objectives Combined chemotherapy and radiotherapy usually associated with various comorbidities especially on rapidly proliferating cells as testis. This study aimed to characterize main constituents of Ocimum basilicum ... -
Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures
(Elsevier, 2019-05-11)Two novel spectrophotometric methodswere presented in thiswork using ethanol as a solvent. The firstmethod was the ratio difference spectrophotometricmethod [RDSM], inwhich the amplitude difference between two ... -
Long lasting in-situ forming implant loaded with raloxifene HCl : An injectable delivery system for treatment of bone injuries
(Elsevier, 2019-09-14)injury is very serious in elder people or osteoporotic patients. In-situ forming implants (IFI) for bone rebuilding are usually poly-lactic-co-glycolic acid (PLGA)-based, which have a burst release effect. This study ... -
Evidence beyond the digitalmedication pill
(European Heart Journal - Cardiovascular Pharmacotherapy, 2019-10-24) -
Euryops pectinatus L. Flower Extract Inhibits P-glycoprotein and Reverses Multi-Drug Resistance in Cancer Cells : A Mechanistic Study
(Molecules, MDPI, 2020-02-03)Euryops pectinatus is a South African ornamental plant belonging to family Asteraceae. The present work evaluates the cytotoxic activity and phytochemical profile of the flower extract. Metabolite profiling was performed ... -
Different aspects in manipulating overlapped spectra used for the analysis of trimebutine maleate and structure elucidation of its degradation products
(Springer, 2019)Background: Four rapid, accurate, and validated stability-indicating spectrophotometric methods have been described in the present work for the analysis of trimebutine maleate (TM) in existence of its degradation products in ... -
Determination of some antiemetic drugs through its native fluorescence or fluorescence quenching of cerrous ammonium sulphate
(Elsevier, 2019-11-23)The manuscript describes two fluorimetric methods for the determination of some antiemetic drugs namely granisetron HCl, ondansetron HCl and tropisetron HCl, used in the management of nausea and vomiting induced by ... -
Design, Regiospecific Green Synthesis, Chemical Computational Analysis, and Antimicrobial Evaluation of Novel Phthalazine Heterocycles
(Wiley Periodicals, Inc., 2019-09)Phthalazines have received considerable attention for their wide antimicrobial activity. Regiospecific nucleophilic attack of 4-benzylphthalazin-1-ol by the 1-oxo rather than the aza group on different alkyl halides ... -
Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity : A Review
(mdpi, 2020-01-06)One of the most widely distributed soft coral species, found especially in shallow waters of the Indo-Pacific region, Red Sea, Mediterranean Sea, and also the Arctic, is genus Sacrophyton. The total number of species ... -
Boosting transdermal delivery of atorvastatin calcium via o/w nanoemulsifying system: Two-step optimization, ex vivo and in vivo evaluation
(Elsevier, 2020-01-23)A nanoemulsion system was designed for Atorvastatin calcium (ATOR) transdermal delivery to overcome its poor bioavailability of (30%) resulting from the extensive first-pass effect and dissolution rate-limited in ... -
Bio-Guided Fractionation of Prenylated Benzaldehyde Derivatives as Potent Antimicrobial and Antibiofilm from Ammi majus L. Fruits-Associated Aspergillus amstelodami
(Molecules, 2019-11-14)Ammi majus L.; Family Apiaceae; is a plant indigenous to Egypt. Its fruits contain bioactive compounds such as furanocoumarins and flavonoids of important biological activities. An endophytic fungus was isolated fromthe ... -
Bactericidal activity of Myrrh extracts and two dosage forms against standard bacterial strains and multidrug‑resistant clinical isolates with GC/MS profiling
(Springer, 2020)Myrrh is the resinous exudate obtained by the incision in Commiphora molmol trees (Family Burseraceae). The bactericidal activity of its hexane extract was compared to its essential oil (MEO) using viable count technique ... -
Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets
(BMC Chemistry, 2019)Comtrex® tablets composed of paracetamol, pseudoephedrine and brompheniramine are widely used for relieving symptoms related to common cold. This study has overcome the challenging dosage form ratio (250:15:1) and proposed ...
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