GPCR molecular pharmacology and drug targeting : shifting paradigms and new directions / edited by Annette Gilchrist.

Abstract

G protein-coupled receptors (GPCRs), are a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs.